Abstract:

Knee dysfunction associated with Knee Osteoarthritis（KOA） is characterized by knee pain， knee stiffness， reduced muscle mass and knee flexion and extension strength. The causes of pain in KOA includes peripheral damaging pain mechanisms as well as pain by osteopathic regulation or central sensitization mechanisms， which is associated with changes in activity in the somatosensory cortex and emotion regulation regions of the brain. Changes in knee motor control in KOA patients include changes in gait and muscle activation patterns， quadriceps muscle weakness， proprioceptive impairment， and limited joint movement， which are closely related to central neuroregulation.

Key words: Osteoarthritis， knee, Neural pathways, Pain, Range of motion